Overview of the Type I Diabetes Genetics Consortium
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چکیده
منابع مشابه
Role of Type 1 Diabetes–Associated SNPs on Autoantibody Positivity in the Type 1 Diabetes Genetics Consortium: Overview
OBJECTIVE Type 1 diabetes (T1D) arises from the autoimmune destruction of the β-cells of the pancreas, resulting in dependence on exogenously administered insulin for survival. Key biomarkers of the autoimmune process in T1D are the occurrence of autoantibodies directed against β-cells and other antigens. The Type 1 Diabetes Genetics Consortium (T1DGC) assembled collections to 1) discover genes...
متن کاملSummary of the Type 1 Diabetes Genetics Consortium Autoantibody Workshop
The Type 1 Diabetes Genetics Consortium (T1DGC) sponsored an Autoantibody Workshop, providing data from a large number of type 1 diabetes-affected sibling pair families with multiple autoantibodies assayed (both islet and nonislet targets) and extensive genetic and clinical information. Multiple groups analyzed the autoantibody data and various forms of genetic data. The groups presented their ...
متن کاملGenetics of type 2 diabetes. On overview
While the genetic causes of monogenic disorders have been successfully identified in the past, the success in dissecting the genetics of complex polygenic diseases has until now been limited. The picture has dramatically changed in 2007 with the introduction of whole genome wide association studies (WGAS) and today variants in at least 18 genes are consitently been associated with T2D. This pro...
متن کاملGenetics of type 2 diabetes. An overview.
While the genetic causes of monogenic disorders have been successfully identified in the past, the success in dissecting the genetics of complex polygenic diseases has until now been limited. The picture has dramatically changed in 2007 with the introduction of whole genome wide association studies (WGAS) and today variants in at least 18 genes are consitently been associated with T2D. This pro...
متن کاملHLA genotyping in the international Type 1 Diabetes Genetics Consortium
BACKGROUND Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes, more detailed information is required for other loci within the HLA region to understand causality and stratify additional risk factors. The Type 1 Diabetes Genetics Consortium (T1DGC) study design included high-resolution genotyping of HLA-A, B, C, DRB1, DQ, and DP ...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2009
ISSN: 1466-4879,1476-5470
DOI: 10.1038/gene.2009.84